The Lewis S. Rosenstiel Award for Distinguished Work in Basic

Medical Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care practic ...

Research Research is "creativity, creative and systematic work undertaken to increase the stock of knowledge". It involves the collection, organization and analysis of evidence to increase understanding of a topic, characterized by a particular att ...

is awarded by

Brandeis University , mottoeng = "Truth even unto its innermost parts" , established = , type = Private research university , accreditation = NECHE , president = Ronald D. Liebowitz , pro ...

. It was established in 1971 "as an expression of the conviction that educational institutions have an important role to play in the encouragement and development of basic

science Science is a systematic endeavor that builds and organizes knowledge in the form of testable explanations and predictions about the universe. Science may be as old as the human species, and some of the earliest archeological evidence for ...

as it applies to

medicine Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care pract ...

". Medals are presented annually at Brandeis University on the basis of recommendations of a panel of scientists selected by the Rosenstiel Basic Medical Sciences Research Center. Awards are given to scientists for recent discoveries of "particular originality" and "importance to basic medical research". A $30,000 prize and a medallion accompanies each award. The Rosenstiel Basic Medical Sciences Research Center, named after Lewis Solon Rosenstiel, was established in 1968, carrying out research in basic medical science.

Recipients

Source
Brandeis University
*2022 Christine Holt and Erin Schuman, for their pioneering work that shed light on the role of local protein synthesis in neuronal development and function. *2021 Robert H. Singer, for his key role in revealing the dynamics of gene expression using high-resolution imaging. *2020

Katalin Karikó Katalin Karikó ( hu, Karikó Katalin, ; born 17 January 1955) is a Hungarian-American biochemist who specializes in RNA-mediated mechanisms. Her research has been the development of in vitro- transcribed mRNA for protein therapies. She co-fo ...

and

Drew Weissman Drew Weissman (born 1959) is an American physician-scientist best known for his contributions to RNA biology. His work helped enable development of effective mRNA vaccines, the best known of which are those for COVID-19 produced by BioNTech/P ...

, for their pioneering work in the modification of nucleic acids to develop RNA therapeutics and vaccines. *2019

David Julius David Jay Julius (born November 4, 1955) is an American physiologist and Nobel Prize laureate known for his work on molecular mechanisms of pain sensation and heat, including the characterization of the TRPV1 and TRPM8 receptors that detect ca ...

and

Ardem Patapoutian Ardem Patapoutian (born 1967) is an Armenian-American molecular biologist, neuroscientist, and Nobel Prize laureate. He is known for his work in characterizing the PIEZO1, PIEZO2, and TRPM8 receptors that detect pressure, menthol, and temperatur ...

, for their remarkable contributions to our understanding of the sensations of temperature, pain and touch. *2018 Stephen C. Harrison, for his fundamental and far-reaching studies of protein structure using X-ray crystallography *2017

Titia de Lange Titia de Lange (born 11 November 1955, in Rotterdam) is the Director of the Anderson Center for Cancer Research, the Leon Hess professor and the head of Laboratory Cell Biology and Genetics at Rockefeller University. De Lange obtained her Mast ...

, for her elucidation of the protection of telomeres and the maintenance of genome stability *2016

Susan Lindquist Susan Lee Lindquist, ForMemRS (June 5, 1949 – October 27, 2016) was an American professor of biology at MIT specializing in molecular biology, particularly the protein folding problem within a family of molecules known as heat-shock proteins ...

(posthum), in recognition of her pioneering work on the mechanisms of protein folding and the severe consequences of protein misfolding that are manifest in disease *2015

Yoshinori Ohsumi is a Japanese cell biologist specializing in autophagy, the process that cells use to destroy and recycle cellular components. Ohsumi is a professor at Tokyo Institute of Technology's Institute of Innovative Research.Yoshinori Ohsumi's He rec ...

, in recognition of his pioneering discoveries of molecular pathways and biological functions of protein degradation by autophagy *2014

Frederick Alt Frederick W. Alt is an American geneticist. He is a member of the Immunology section of the National Academy of Sciences and a Charles A. Janeway Professor of Pediatrics, and Professor of Genetics at Harvard Medical School. He is the Director ...

, in recognition of his pioneering work in elucidating the mechanisms of genome rearrangements in immune and cancer cells Rosenstiel Award 2014
/ref> *2013

Winfried Denk Winfried Denk (born November 12, 1957 in Munich) is a German physicist. He built the first two-photon microscope while he was a graduate student (and briefly a postdoc) in Watt W. Webb's lab at Cornell University, in 1989. Early life and educa ...

David Tank David W. Tank is an American molecular biologist and neuroscientist who is the Henry L. Hillman Professor in Molecular Biology at Princeton University and the co-director of the Princeton Neuroscience Institute along with psychology professor Jo ...

and

Watt W. Webb Watt Wetmore Webb (August 27, 1927 – October 29, 2020) was an American biophysicist, known for his co-invention (with Winfried Denk and Jim Strickler) of multiphoton microscopy in 1990. Early life and education Watt Wetmore Webb was born on ...

, in recognition of their invention of multiphoton fluorescence microscopy and its application to illuminating the function of brain microcircuits *2012

Stephen J. Elledge Stephen Joseph Elledge (born August 7, 1956, in Paris Illinois) is an American geneticist. He is currently the Gregor Mendel Professor of Genetics and Medicine in the Department of Genetics at Harvard Medical School and in the Division of Geneti ...

, for elucidating how eukaryotic cells sense and respond to DNA damage *2011

Nahum Sonenberg Nahum Sonenberg, ( he, נחום סוננברג; born December 29, 1946) is an Israeli Canadian microbiologist and biochemist. He is a James McGill professor of biochemistry at McGill University in Montreal, Quebec, Canada.

, for his transformative studies of the control of protein synthesis in mammalian cells *2010 C. David Allis and

Michael Grunstein Michael Grunstein (born 1946, in Romania) is a Distinguished Professor Emeritus of Biological Chemistry at the David Geffen School of Medicine at UCLA. The only surviving child of Holocaust survivors, he obtained his Bachelor of Science degree fr ...

, for their discovery that histones and histone acetylation directly regulate transcription *2009

Jules Hoffman Jules A. Hoffmann (; born 2 August 1941) is a Luxembourg-born French biologist. During his youth, growing up in Luxembourg, he developed a strong interest in insects under the influence of his father, Jos Hoffmann. This eventually resulted in the y ...

and

Ruslan Medzhitov Ruslan Maksutovich Medzhitov (born March 12, 1966) is a professor of immunobiology at Yale School of Medicine, a member of Yale Cancer Center, and a Howard Hughes Medical Institute investigator. His research focuses on the analysis of the innate i ...

, for elucidating the mechanisms of innate immunity *2008

John Gurdon Sir John Bertrand Gurdon (born 2 October 1933) is a British developmental biologist. He is best known for his pioneering research in nuclear transplantation and cloning. He was awarded the Lasker Award in 2009. In 2012, he and Shinya Yamanaka ...

Irving Weissman Irving Lerner "Irv" Weissman (born Great Falls, Montana, October 21, 1939) is a Professor of Pathology and Developmental Biology at Stanford University where he is the Director of the Stanford Institute of Stem Cell Biology and Regenerative Medic ...

and

Shinya Yamanaka is a Japanese stem cell researcher and a Nobel Prize laureate. He serves as the director of Center for iPS Cell (induced Pluripotent Stem Cell) Research and Application and a professor at the Institute for Frontier Medical Sciences at Kyoto ...

, for their pioneering work in the field of stem cell research *2007 F.-Ulrich Hartl and Arthur L. Horwich, for their pioneering work in the field of protein-mediated protein folding *2006

Mary F. Lyon Mary Frances Lyon (15 May 1925 – 25 December 2014) was an English geneticist best known for her discovery of X-chromosome inactivation, an important biological phenomenon. Early life and education Mary Lyon was born on 15 May 1925 in Norwic ...

Davor Solter Davor Solter (born March 22, 1941) is a Yugoslavian-born developmental biologist, particularly known for his pioneering work on mammalian genomic imprinting. He is Emeritus Member and Director, Max Planck Institute of Immunobiology and Epigenetics ...

and

Azim Surani Azim Surani (born 1945 in Kisumu, Kenya) is a Kenyan-British developmental biologist who has been Marshall–Walton Professor at the Wellcome Trust/Cancer Research UK Gurdon Institute at the University of Cambridge since 1992, and Director of ...

, for their pioneering work on epigenetic gene regulation in mammalian embryos *2005

Martin Chalfie Martin Lee Chalfie (born January 15, 1947) is an American scientist. He is University Professor at Columbia University. He shared the 2008 Nobel Prize in Chemistry along with Osamu Shimomura and Roger Y. Tsien "for the discovery and development ...

and Roger Y. Tsien, for their pioneering development of powerful new tools that allow the direct visualization of molecules in living cells *2004

Andrew Z. Fire Andrew Zachary Fire (born April 27, 1959) is an American biologist and professor of pathology and of genetics at the Stanford University School of Medicine. He was awarded the 2006 Nobel Prize in Physiology or Medicine, along with Craig C. Mello ...

Craig C. Mello Craig Cameron Mello (born October 18, 1960) is an American biologist and professor of molecular medicine at the University of Massachusetts Medical School in Worcester, Massachusetts. He was awarded the 2006 Nobel Prize for Physiology or Medicine, ...

Victor Ambros Victor R. Ambros (born 1953, Hanover, New Hampshire) is an American developmental biologist who discovered the first known microRNA (miRNA). He is a professor at the University of Massachusetts Medical School in Worcester, Massachusetts. Back ...

and

Gary Ruvkun Gary Bruce Ruvkun (born March 1952, Berkeley, California) is an American molecular biologist at Massachusetts General Hospital and professor of genetics at Harvard Medical School in Boston. Ruvkun discovered the mechanism by which ''lin-4'', th ...

, for their pioneering achievements in the discovery of gene silencing by double-stranded RNA *2003

Masakazu Konishi was a Japanese neurobiologist, known for his research on the neuroscience underlying the behavior of owls and songbirds. Early life and education Konishi was born on 17 February 1933 in Kyoto, Japan, the only child of poor "Nishijin" weavers ...

Peter Marler Peter Robert Marler ForMemRS (February 24, 1928 – July 5, 2014) was a British-born American ethologist and zoosemiotician known for his research on animal sign communication and the science of bird song. A 1964 Guggenheim Fellow, he was emeri ...

and

Fernando Nottebohm Fernando Nottebohm (born 1940 in Buenos Aires) is a neuroscientist and the Dorothea L. Leonhardt Professor at Rockefeller University, as well as being head of the Laboratory of Animal Behavior and director of the Field Research Center for Ecology a ...

, for their pioneering achievements in the ethology and neurology of birdsong *2002

Ira Herskowitz Ira Herskowitz (July 14, 1946 – April 28, 2003) was an American phage and yeast geneticist geneticist who studied genetic regulatory circuits and mechanisms. He was particularly noted for his work on mating type switching and cellular different ...

, for his pioneering achievements in yeast genetics and cell biology *2001

Joan A. Steitz Joan Elaine Argetsinger Steitz (born January 26, 1941) is Sterling Professor of Molecular Biophysics and Biochemistry at Yale University and Investigator at the Howard Hughes Medical Institute. She is known for her discoveries involving RNA, inc ...

, for her work in establishing a sub-field of molecular biology concerning small nuclear ribonucleoproteins *2000 Peter B. Moore, Harry F. Noller, Jr. and Thomas A. Steitz, for their discovery that peptide bond formation on the ribosome is catalyzed exclusively by ribosomal RNA *1999

Roderick MacKinnon Roderick MacKinnon (born February 19, 1956) is an American biophysicist, neuroscientist, and businessman. He is a professor of Molecular Neurobiology and Biophysics at Rockefeller University who won the Nobel Prize in Chemistry together with Peter ...

, for his research into the molecular foundations of electrical signal generation in neurons and other types of cells *1998

Elizabeth Blackburn Elizabeth Helen Blackburn, (born 26 November 1948) is an Australian-American Nobel laureate who is the former president of the Salk Institute for Biological Studies. Previously she was a biological researcher at the University of California, S ...

and

Carol Greider Carolyn Widney Greider (born April 15, 1961) is an American molecular biologist and Nobel laureate. She joined the University of California, Santa Cruz as a Distinguished Professor in the department of molecular, cell, and developmental biology ...

, for their outstanding work on the maintenance of telomeres *1997

H. Robert Horvitz Howard Robert Horvitz ForMemRS NAS AAA&S APS NAM (born May 8, 1947) is an American biologist best known for his research on the nematode worm ''Caenorhabditis elegans'', for which he was awarded the 2002 Nobel Prize in Physiology or Medicine, t ...

and

John E. Sulston Sir John Edward Sulston (27 March 1942 – 6 March 2018) was a British biologist and academic who won the Nobel Prize in Physiology or Medicine for his work on the cell lineage and genome of the worm '' Caenorhabditis elegans'' in 2002 wit ...

, for their pioneering studies of cell lineage in the nematode worm *1996

Richard Axel Richard Axel (born July 2, 1946) is an American molecular biologist and university professor in the Department of Neuroscience at Columbia University and investigator at the Howard Hughes Medical Institute. His work on the olfactory system won hi ...

Linda B. Buck Linda Brown Buck (born January 29, 1947) is an American biologist best known for her work on the olfactory system. She was awarded the 2004 Nobel Prize in Physiology or Medicine, along with Richard Axel, for their work on olfactory receptors. She ...

and

A. James Hudspeth A. James Hudspeth is the F.M. Kirby Professor at Rockefeller University in New York City, where he is director of the F.M. Kirby Center for Sensory Neuroscience. His laboratory studies the physiological basis of hearing. Early life and education ...

, for establishing the molecular basis of the senses of smell and hearing *1995 Thomas D. Pollard and

James A. Spudich James A. Spudich () is an American scientist and professor. He is the Douglass M. and Nola Leishman Professor of Biochemistry and of Cardiovascular Disease at Stanford University and works on the molecular basis of muscle contraction. He was awar ...

, for their fundamental contributions to our understanding of molecular motors *1994

Robert G. Roeder Robert G. Roeder (born June 3, 1942, in Boonville, Indiana, United States) is an American biochemist. He is known as a pioneer scientist in eukaryotic transcription. He discovered three distinct nuclear RNA polymerases in 1969 and characterized ...

and

Robert Tjian Robert Tjian (; born 1949) is a Hong Kong-born American biochemist best known for his work on eukaryotic transcription. He is currently Professor of Biochemistry and Molecular Biology at the University of California, Berkeley and an Investigator ...

, for their outstanding work on eukaryotic transcription regulation *1993 James E. Rothman and

Randy Schekman Randy Wayne Schekman (born December 30, 1948) is an American cell biologist at the University of California, Berkeley, former editor-in-chief of ''Proceedings of the National Academy of Sciences'' and former editor of ''Annual Review of Cell and ...

, for determining the components of the secretory pathway *1992

Paul Nurse Sir Paul Maxime Nurse (born 25 January 1949) is an English geneticist, former President of the Royal Society and Chief Executive and Director of the Francis Crick Institute. He was awarded the 2001 Nobel Prize in Physiology or Medicine along ...

and

Leland H. Hartwell Leland Harrison (Lee) Hartwell (born October 30, 1939 in Los Angeles, California) is former president and director of the Fred Hutchinson Cancer Research Center in Seattle, Washington. He shared the 2001 Nobel Prize in Physiology or Medicine wit ...

, for establishing the details of the control of eukaryotic cell cycle *1991

David Botstein David Botstein (born September 8, 1942) is an American biologist serving as the chief scientific officer of Calico. He served as the director of the Lewis-Sigler Institute for Integrative Genomics at Princeton University from 2003 to 2013, where ...

, Raymond L. White and

Ronald W. Davis Ronald Wayne "Ron" Davis (born July 17, 1941) is Professor of Biochemistry & Genetics, and Director of the Stanford Genome Technology Center at Stanford University. Davis is a researcher in biotechnology and molecular genetics, particularly activ ...

, for creating the methods by which variations in the human genome can be detected and analyzed *1990 Richard Henderson and Peter Nigel Tripp Unwin, for determining the first structure of an integral membrane protein *1989

Christiane Nüsslein-Volhard Christiane (Janni) Nüsslein-Volhard (; born 20 October 1942) is a German developmental biologist and a 1995 Nobel Prize in Physiology or Medicine laureate. She is the only woman from Germany to have received a Nobel Prize in the sciences. Nü ...

and

Edward B. Lewis Edward Butts Lewis (May 20, 1918 – July 21, 2004) was an American geneticist, a corecipient of the 1995 Nobel Prize in Physiology or Medicine. He helped to found the field of evolutionary developmental biology. Early life Lewis was born in Wi ...

, for pioneering studies of eukaryotic development *1988

Sidney Altman Sidney Altman (May 7, 1939 – April 5, 2022) was a Canadian-American molecular biologist, who was the Sterling Professor of Molecular, Cellular, and Developmental Biology and Chemistry at Yale University. In 1989, he shared the Nobel Prize in ...

and

Thomas R. Cech Thomas Robert Cech (born December 8, 1947) is an American chemist who shared the 1989 Nobel Prize in Chemistry with Sidney Altman, for their discovery of the catalytic properties of RNA. Cech discovered that RNA could itself cut strands of RNA, ...

, for discovering RNA catalysis *1987

Shinya Inoué was a Japanese American biophysicist and cell biologist, a member of the National Academy of Sciences. His research field was the visualization of dynamic processes within living cells using light microscopy. Research Inoué can be considered th ...

, for his innovations in light microscopy *1986 Harland G. Wood, for his outstanding work on enzyme function *1985

Seymour Benzer Seymour Benzer (October 15, 1921 – November 30, 2007) was an American physicist, molecular biologist and behavioral geneticist. His career began during the molecular biology revolution of the 1950s, and he eventually rose to prominence in the ...

and

Sydney Brenner Sydney Brenner (13 January 1927 – 5 April 2019) was a South African biologist. In 2002, he shared the Nobel Prize in Physiology or Medicine with H. Robert Horvitz and Sir John E. Sulston. Brenner made significant contributions to work ...

, for founding modern eukaryotic genetics *1984

Donald D. Brown Donald David Brown (December 30, 1931 – May 31, 2023) was an American biologist and one of the founders of molecular embryology. Early life Brown was born in Cincinnati, Ohio to Dr. Albert Brown, an Ophthalmology, ophthalmologist, and Lo ...

and Robert L. Letsinger, for their seminal work on development *1983 Eric R. Kandel and

Daniel E. Koshland, Jr. Daniel Edward Koshland Jr. (March 30, 1920July 23, 2007) was an American biochemist. He reorganized the study of biology at the University of California, Berkeley, and was the editor of the leading U.S. science journal, ''Science'', from 1985 ...

, for pioneering contributions to sensory transduction *1982

Keith R. Porter Keith Roberts Porter (June 11, 1912 – May 2, 1997) was a Canadian-American cell biologist. He created pioneering biology techniques and research using electron microscopy of cells. Porter also contributed to the development of other experiment ...

and

Alexander Rich Alexander Rich (15 November 1924 – 27 April 2015) was an American biologist and biophysicist. He was the William Thompson Sedgwick Professor of Biophysics at MIT (since 1958) and Harvard Medical School. Rich earned an A.B. (''magna cum laud ...

*1981 Stanley Cohen,

Rita Levi-Montalcini Rita Levi-Montalcini (, ; 22 April 1909 – 30 December 2012) was an Italian Nobel laureate, honored for her work in neurobiology. She was awarded the 1986 Nobel Prize in Physiology or Medicine jointly with colleague Stanley Cohen for the ...

and Gordon H. Sato *1980

Elias J. Corey Elias James Corey (born July 12, 1928) is an American organic chemist. In 1990, he won the Nobel Prize in Chemistry "for his development of the theory and methodology of organic synthesis", specifically retrosynthetic analysis. Regarded by many ...

Bengt I. Samuelsson Bengt Ingemar Samuelsson (born 21 May 1934) is a Swedish biochemist. He shared with Sune K. Bergström and John R. Vane the 1982 Nobel Prize for Physiology or Medicine for discoveries concerning prostaglandins and related substances. Education a ...

and

Frank H. Westheimer Frank Henry Westheimer NAS ForMemRS APS (January 15, 1912 – April 14, 2007) was an American chemist. He taught at the University of Chicago from 1936 to 1954, and at Harvard University from 1953 to 1983, becoming the Morris Loeb Professor of ...

*1979

Howard Green Howard Green Jr. (born January 12, 1979) is a former American football nose tackle who played professionally in the National Football League (NFL). He was drafted by the Houston Texans in the sixth round of the 2002 NFL draft. He played colle ...

and

Beatrice Mintz Beatrice Mintz (January 24, 1921 – January 3, 2022) was an American embryologist who contributed to the understanding of genetic modification, cellular differentiation, and cancer, particularly melanoma.Martha J. Bailey, ''American women in ...

*1978

César Milstein César Milstein, CH, FRS (8 October 1927 – 24 March 2002) was an Argentine biochemist in the field of antibody research. Milstein shared the Nobel Prize in Physiology or Medicine in 1984 with Niels Kaj Jerne and Georges J. F. Köhler for d ...

*1977

Barbara McClintock Barbara McClintock (June 16, 1902 – September 2, 1992) was an American scientist and cytogeneticist who was awarded the 1983 Nobel Prize in Physiology or Medicine. McClintock received her PhD in botany from Cornell University in 1927. There s ...

*1976

Peter D. Mitchell Peter Dennis Mitchell, FRS (29 September 1920 – 10 April 1992) was a British biochemist who was awarded the 1978 Nobel Prize for Chemistry for his discovery of the chemiosmotic mechanism of ATP synthesis. Education and early life Mitc ...

*1975

Bruce Ames Bruce Nathan Ames (born December 16, 1928) is an American biochemist. He is a professor of Biochemistry and Molecular Biology Emeritus at the University of California, Berkeley, and was a senior scientist at Children's Hospital Oakland Research I ...

, James A. Miller and Elizabeth C. Miller *1974 Arthur B. Pardee and H. Edwin Umbarger *1973 H. Ronald Kaback and Saul Roseman *1972

Boris Ephrussi Boris Ephrussi (russian: Борис Самойлович Эфрусси; 9 May 1901 – 2 May 1979), Professor of Genetics at the University of Paris, was a Russo- French geneticist. Boris was born on 9 May 1901 into a Jewish family. His father, ...

*1971

David H. Hubel David Hunter Hubel (February 27, 1926 – September 22, 2013) was a Canadian American neurophysiologist noted for his studies of the structure and function of the visual cortex. He was co-recipient with Torsten Wiesel of the 1981 Nobel Pri ...

and Torsten N. Wiesel

References

External links

American Jewish Archives
Lewis S. Rosentiel i
Family Tree
{{Brandeis University Medicine awards Awards established in 1971 Brandeis University

Recipients

See also

References

External links